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The precise mechanism as to how unrepaired single-strand break intermediates are generated during the DNA repair pathways is unknown. The overall goal of the lab is to better understand the biological importance and molecular mechanism of the sequential flow of DNA intermediates through the DNA repair pathways under oxidative stress cellular conditions.

The Caglayan lab in the Department of Biochemistry and Molecular Biology has multiple lab positions available for self-motivated, dedicated, dynamic, and responsible individuals to become part of a growing research team and program.